Accuris SmartDrop Nano Spectrophotometer | Microvolume UV/Vis Spectrophotometer

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Model: SmartDrop L
Electric: 115V
Sale price$5,481.00 Regular price$6,090.00

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 SmartDrop Nano Spectrophotometers: Microvolume Analysis for DNA, RNA, and Protein Quantification

Discover Accuris SmartDrop™ nano spectrophotometers for quick, accurate microvolume analysis of DNA, RNA, and proteins. Touch screen control, built-in printer, and OD600 readings.

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SmartDrop Nano Spectrophotometers: Revolutionizing Microvolume Analysis

SmartDrop family of microvolume UV/Vis spectrophotometer

Are you looking for efficient microvolume analysis of DNA, RNA, and proteins? The Accuris SmartDrop™ series of nano spectrophotometers offers rapid and precise quantification using minimal sample volumes. Here's why researchers choose SmartDrop:

Key Features:

  • Quick and accurate results from a single droplet
  • User-friendly 7" touch screen control panel
  • No PC or software required
  • Built-in printer for instant data access
  • Cuvette port for OD600 readings
  • XF model includes fluorometer for sensitive DNA quantification

Benefits of SmartDrop Nano Spectrophotometers:

  1. Microvolume Analysis: Eliminate dilutions for more accurate results
  2. User-Friendly Interface: Icon-driven menus and preprogrammed protocols
  3. Versatile Applications: Quantify DNA, RNA, and proteins in seconds
  4. Data Management: Print, save, or export results via USB as Excel files
  5. OD600 Readings: Includes cuvette port and two optical glass cuvettes

Choose the SmartDrop Model That Works Best For You

SmartDrop L

  • Ideal for basic DNA/RNA/protein quantification and purity
  • Affordable LED and silicon detector technology
  • Fixed 0.5mm path length, detect up to 2500ng/µl of dsDNA

SmartDrop L is the affordable choice for laboratories needing to determine nucleic acid and protein concentrations and purity of samples. The LED light source and silicon photocell sensor provide readings at 260 and 280nm. Samples from 1.0 to 2.0µl are loaded directly on the pedestal. Results are provided in about 5 seconds. The software automatically
calculates and displays 260/280 ratios.

SmartDrop X

  • Full-spectrum absorbance scans from 200 to 800nm
  • Quickly calculates and displays 260/280 and 260/230 ratios
  • Long-life Xenon lamp with precision monochromator
  • Auto-ranging path lengths of 0.2mm and 1.0mm
  • Detect up to 4,500 ng/µl of dsDNA without dilution

A full spectrum UV-Vis spectrophotometer, SmartDrop X requires 0.5 to 2.0µl of sample. In addition to nucleic acid and protein calculations, the software has preset programs for BCA, Bradford and Lowry assays. A full spectrum analysis can be performed in about 6 seconds, aiding in the
identification of unknowns. Up to 5 specific points on the spectrum can be selected for colorimetric readings output. The long life Xenon lamp source requires no warm up and is paired with a highly sensitive CCD detector. To provide the most accurate results, the 
SmartDrop X utilizes 2 path lengths.

SmartDrop XF – Spectrophotometer + Fluorometer

  • Full-spectrum absorbance scanning and calculations of
    260/280 and 260/230 ratios
  • Long-life Xenon lamp with precision monochromator
  • Auto-ranging path lengths of 0.05mm, 0.2mm and
  • Detect up to 15,000ng/µl of dsDNA without dilution
  • Integrated fluorometer for sensitive quantitation of low
    concentration nucleic acids

This top of the line spectrophotometer can perform not only UV-Vis readings in the range of 200-800nm but also fluorescence readings. Like the SmartDrop X, the SmartDrop XF features predefined programs for nucleic acids, proteins, and various colorimetric assays. The patented, motorized system gently stretches the sample column and allows for three different path lengths, providing accurate readings of samples from 0.5 to 2.0µl without dilution.

The integrated fluorometer yields more accurate, sensitive and selective quantitation of nucleic acids. The blue light channel (460nm) is useful for detection of dyes such as PicoGreen and RiboGreen as well as GFP and fluorescein. UV, green and red channel models are available upon

Accuris DNA Quantification Kits

Accuris DNA Quantification Kits are designed for accurate fluorescent quantification of dsDNA using instruments such as the Qubit®, SmartDrop™ XF, and microplate readers.  The reagents are highly selective for double-stranded DNA (dsDNA); quantification results will not be skewed by single-stranded DNA (ssDNA), RNA, protein, or nucleotides in a sample.  Included with each kit are a concentrated fluorescent assay reagent, dilution buffer, and ready-to-use DNA standards.  The assay reagent is diluted using the buffer provided, sample is added (1 µL to 20 µL), and the concentration determined using an appropriate fluorometer instrument that utilizes blue excitation (460 ± 20 nm) and measures green fluorescence (525-570 nm).

High Sensitivity dsDNA Assay Kit
The Accuris High Sensitivity Kit provides an accurate method to quantify low concentration dsDNA samples.  The assay kit is designed to be accurate for initial DNA sample concentrations of 0.005–120 ng/µl, providing a detection range of 0.1–120 ng.

Broad Range dsDNA Assay Kit
The Accuris Broad Range Kit provides an accurate method to quantify dsDNA samples that have a broad concentration range starting at 0.2 ng/µL. The assay kit is designed to be accurate for initial DNA sample concentrations of 0.2 to 2,000 ng/µL, providing a detection range of 4−2,000 ng.

What are the sample size requirements for the Accuris SmartDrop Nano Spectrophotometer?

Surface tension is a critical factor in the formation of the sample column for measurement. The hydrophobic interactions between water molecules in a sample solution is key in creating & maintaining surface tension. The presence of solutes (proteins, DNA, RNA, salt ions, detergent molecules) significantly reduces surface tension and hinders the formation of the sample column. For most samples, a 1μL sample size is enough; however, to ensure accurate and precise measurements, a 2μL sample size is recommended to allow the formation of the sample column for measurement.

To ensure precise and accurate measurements, it is essential that a complete liquid column forms between the upper pedestal and lower pedestal. It is recommended that a precision pipettor (0-2μL) be used to dispense samples. 

Is there carryover from sample measurements?

To prevent sample carryover, use a soft laboratory wipe and deionized water to clean both pedestals in between sample measurements.


Model SmartDrop L (NS1000) SmartDrop X (NS1010) SmartDrop XF (NS1020)
Display 7-inch touch screen 7-inch touch screen 7-inch touch screen
Minimum sample size 1.0µl – 2.0µl 0.5µl – 2.0µl 0.5µl – 2.0µl
Path length 0.5mm 0.2mm, 1.0mm 0.05mm, 0.2mm, 1.0mm
Light source UV LED Xenon Flash Lamp Xenon Flash Lamp
Detector UV Silicon Photocell 2048 Element Linear Silicon CCD Array 2048 Element Linear Silicon CCD Array
Wavelength 260, 280, & 600nm 200 – 800nm (1nm steps) 200 – 800nm (1nm steps)
Absorbance range 0.2 – 50 A (10mm equivalent) 0.04 – 90 A (10mm equivalent) 0.04 – 300 A (10mm equivalent)
Absorbance precision 0.005 A 0.003 A 0.003 A
Lower limit of detection dsDNA: 10ng/µl; BSA: 0.1 mg/ml dsDNA: 2ng/µl; BSA: 0.1mg/ml dsDNA: 2ng/µl ; BSA: 0.1mg/ml
Upper limit of detection dsDNA: 2,500ng/µl; BSA: 75.0 mg/ml dsDNA: 4,500ng/µl; BSA: 135mg/ml dsDNA: 15,000ng/µl; BSA: 360mg/ml
Detection time < 6 seconds < 5 seconds < 6 seconds
Communication ports USB for data export USB for data export USB for data export
Voltage input DC 24V, 2A DC 24V, 2A DC 24V, 2A
Power 25W 25W 25W
Dimensions (WxDxH) 8.2 x 11.0 x 7.3 in. /   20.8 x 28.0 x 18.6cm 8.3 x 10.6 x 7.2 in. / 21.0 x 26.8 x 18.1cm 8.2 x 12.6 x 7.3 in. / 20.8 x 32.0 x 18.6cm
Weight 3.6 kg / 7.9 lbs 2.8 kg / 6.2 lbs 3.6 kg / 7.9 lbs
Cuvette OD600 detection
Absorbance range 0.0 – 4.0 A 0.0 – 4.0 A 0.0 – 4.0 A
Absorbance stability [0,3) ≤ 0.5%, [3,4) ≤ 2% [0,3) ≤ 0.5%, [3,4) ≤ 2% [0,3) ≤ 0.5%, [3,4) ≤ 2%
Absorbance repeatibility [0,3) ≤ 0.5%, [3,4) ≤ 2% [0,3) ≤ 0.5%, [3,4) ≤ 2% [0,3) ≤ 0.5%, [3,4) ≤ 2%
Absorbance precision [0,2) ≤ 0.005 A, [2,3) ≤ 1%, [3,4) ≤ 2% [0,2) ≤ 0.005 A, [2,3) ≤ 1%, [3,4) ≤ 2% [0,2) ≤ 0.005 A, [2,3) ≤ 1%, [3,4) ≤ 2%
Fluorescence detection
Excitation/Emission N/A N/A 460 ± 20nm / 525-570nm
Sensitivity N/A N/A dsDNA: 0.5pg/µl
Linearity N/A N/A R² ≥ 0.995
Repeatability N/A N/A ≤ 1.5%
Stability N/A N/A ≤ 1.5%

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